Abstract
Introduction: At present, the problem of pharmacological correction of free radical processess emerges full-blown. The aim of the study is an experimental study of the neuroprotective effect of taurine and 3-hydroxypyridine derivatives.
 Materials and methods: The study was performed in Wistar rats. The neuroprotective effect of the substances was studied in the intracerebral hemorrhage model.
 Results and discussion: The administration of the studied substances had a positive effect on the survival of the animals within the first day (50% of rats died in the control group, 30% – in the Mexidol- and Ethoxidol-treated groups, and 20% – in LKhT 3-17-treated group). Within the first day after the surgery, all rats with stroke had severe neurological disorders. However, by the 3rd day, the Ethoxidol- and LKhT 3-17-treated rats had a lower neurological deficit. By Day 14, all groups of animals treated with the test substances had a lower severity of post-stroke disorders than those in the control group, which was evident as a 1.5-time lower McGraw Stroke Index score. LKhT 3-17 substance showed the most pronounced neuroprotective effect.
 Conclusions: The studied derivatives of taurine and 3-hydroxypyridine have a neuroprotective effect, which is manifested in the lower severity of neurological disorders,a more rapid reduction in the signs of neurodegeneration and accelerated hemorrhage processes.
Highlights
At present, the problem of pharmacological correction of free radical processess emerges full-blown
Reduction of the local cerebral blood flow in the area around hemorrhage triggers ischemic pathobiochemical cascades in the brain matter: changes in the glutamate and calcium metabolism, free radical reactions, lipid peroxidation, excessive synthesis of nitric oxide, activation of astro- and microglial cell pools, and immune changes and local inflammation associated with these changes
The aim of this study was the experimental study of the therapeutic effects of taurine and 3-hydroxypyridine derivatives with potential neuroprotective effects in the intracerebral hemorrhage model in rats
Summary
The problem of pharmacological correction of free radical processess emerges full-blown. The neuroprotective effect of the substances was studied in the intracerebral hemorrhage model. Results and discussion: The administration of the studied substances had a positive effect on the survival of the animals within the first day (50% of rats died in the control group, 30% – in the Mexidol- and Ethoxidol-treated groups, and 20% – in LKhT 3-17-treated group). Conclusions: The studied derivatives of taurine and 3-hydroxypyridine have a neuroprotective effect, which is manifested in the lower severity of neurological disorders,a more rapid reduction in the signs of neurodegeneration and accelerated hemorrhage processes. Reduction of the local cerebral blood flow in the area around hemorrhage triggers ischemic pathobiochemical cascades in the brain matter: changes in the glutamate and calcium metabolism, free radical reactions, lipid peroxidation, excessive synthesis of nitric oxide, activation of astro- and microglial cell pools, and immune changes and local inflammation associated with these changes. Fe3+ ions, which are a powerful cellular oxidant, intensify lipid peroxidation and stimulate the formation of a large number of free radicals, are responsible for the permanent brain damage (Walsh et al 2000)
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