Abstract
Thiazolidinediones are a synthetic ligand of peroxisome proliferator-activated receptor γ （PPARγ）. PPARγ has certain protective effects for several types of tissues. The research covers the areas of glucose, lipid metabolism, cancer and atherosclerosis, etc, At present, the roles of thiazolidinediones in central nervous system diseases have received roach attention, such as cerebral infarction, multiple sclerosis, and Alzheimer＇s disease. This article reviews the effects of PPARγ ligand thiazolidinediones on inhibiting the proliferation of glial ceils, promoting angiogenesis, and antagonizing neuronal apoptosis after cerebral ischemia. Key words: PPARγ; Thiazolidmediones; Thiadiazoles; Brain lschemia; Neuroprotective Agents
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