Abstract
neuroprotective effects of HQ against ischemic damage in a focal cerebral ischemia rat model. Results: It was proven that preand post-treatment with 100mg/kg of HQ protects from ischemia-induced cerebral damage, which was confirmed by evaluation of neurological deficit, PET (Positron-emission tomography) and TTC (2,3,5triphenyltetrazoliumchloride) staining. In addition, preand post-treatment with 100mg/kg of HQ significantly attenuated ischemia-induced Evans blue dye extravasation, and significantly increased the immunoreactivities and protein levels of SMI-71 and glucose transporter-1 (GLUT-1), which were well-known as useful makers of endothelial cell, in ischemic cortex compared to vehicletreated-group. Conclusion: Briefly, these results indicate that preand posttreatment with HQ can protect from ischemic damage induced by transient focal cerebral ischemia, and the neuroprotective effects of HQmaybe closely associatedwith thepreventionof BBBdisruption via increasing of SMI-71 and GLUT-1 expressions.
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