Neuroprotective Effect of Phloroglucinol in Cisplatin Induced Peripheral Neuropathy

Abstract

Cisplatin induced peripheral neuropathy is one of the major challenge in oncology. There is growing evidence suggesting that physical damage by cisplatin leads to functional impairment in neurons through oxidative stress inflammation apoptosis and electrophysiological disturbances. So the aim of the study is to evaluate the neuroprotective effect of phloroglucinol against cisplatin induced peripheral neuropathy in rats. Neuropathy in adult male Wistar rats was induced by injecting cisplatin 2 mgkg i.p twice a week for 6 weeks and then rats were treated with phloroglucinol 250 amp 400 mgkg p.o for 8 weeks. At the end of the study body weight and haemogram were estimated. Behavioural tests including cold and hot hyperalgesia mechano-tactile allodynia and mechanical hyperalgesia were also carried out. Further sciatic nerve conduction velocity antioxidant enzymes and nitric oxide level were estimated in sciatic nerve homogenate. Treatment with phloroglucinol protected the neurons from neurotoxic effects of cisplatin by improving hyperalgesia nerve conduction velocity and oxidative stress. Our results suggest that phloroglucinol represents a new promise to use as supportive drug to protect against cisplatin induced neuropathy in oncology.