Neuroprotective effect of barringtonia Racemosa on haloperidol induced catalepsy in experimental animal model

Abstract

Barringtonia racemosa L. (Lecythidaceae) is an ancient and mangrove associate plant. It possesses antidepressant activity, antioxidant activity, anti-inflammatory activity, antidiabetic activity and antifungal activity. In the present study, we investigated the anticataleptic activity of extract of Barringtonia racemosa fruit on haloperidol induced catalepsy in rats. Chloroform extract of Barringtonia racemosa fruit was prepared and evaluated for anti-cataleptic property. The rats were divided into 4 groups (n=6). Group I is served as control. Group II [(haloperidol 1.0 mg/kg body weight, i. p. in Haloperidol induced catalepsy (HIC)]. Group III (CEBR, 200 mg/kg body weight, p. o.). Group IV (CEBR, 400 mg/kg body weight respectively p. o.). The anti-cataleptic effect of Barringtonia racemosa, was evaluated by locomotor activity and rota rod test using rat models. Barringtonia racemosa extract (200 and 400 mg/kg body weight, p. o.) was found to decrease the duration of catalepsy significantly (P < 0.01) in standard bar test as compared to haloperidol group. Comparatively, CEBR (400 mg/kg body weight, p. o.) was more potent anti-cataleptic activity than CEBR (200 mg/kg body weight, p. o.)