NEUROPROTECTIVE EFEFCTS OF ESTRADIOL ON ANTIOXIDANT STATUS, CALCIUM HOMEOSTASIS AND GLUCOSE TRANSPORTER IN AGING FEMALE RAT BRAIN

Abstract

Event Abstract Back to Event NEUROPROTECTIVE EFEFCTS OF ESTRADIOL ON ANTIOXIDANT STATUS, CALCIUM HOMEOSTASIS AND GLUCOSE TRANSPORTER IN AGING FEMALE RAT BRAIN Pardeep Kumar1*, R K. Kale1, S M. Cowsik1 and N. Baquer1 1 Jawaharlal Nehru University,, School of Life Sciences, India During normal aging, brain experiences structural, molecular, and functional alterations. Aging in females and males is considered as the end of natural protection against age related diseases like osteoporosis, coronary heart disease, diabetes, Alzheimer’s disease and Parkinson’s disease. Protection from age-related disorders is provided by several factors, including estrogens. These changes increase during menopausal condition in females when the level of estradiol is decreased. The objective of this study was to observe the changes in activities of superoxide dismutase (SOD), glutathione S-transferase (GST), Ca2+ATPase, intracellular calcium levels, DNA degradation and glucose transporter 4 (GLUT4) occurring in brains of female albino Wistar rats of 3 months (young), 12 months (adult) and 24 months (old) age groups, and to see whether these changes are restored to normal levels after exogenous administration of estradiol (0.1 µg/gm body weight for one month). The results obtained in the present work revealed that normal aging was associated with significant decrease in the activities of SOD, GST, Ca2+ATPase and GLUT4 levels in the brains of aging female rats, and an increase in DNA degradation and intracellular calcium levels. Administration of estradiol brought these changes to near normalcy. It can therefore be concluded that estradiol’s beneficial effects seemed to arise from its antioxidant and antilipidperoxidative effects, implying an overall neuroprotective and anti-aging action. The results of this study will be useful for pharmacological modification of the aging process and applying new strategies for control of age related disorders. Conference: Neuroinformatics 2010 , Kobe, Japan, 30 Aug - 1 Sep, 2010. Presentation Type: Oral Presentation Topic: Clinical neuroscience Citation: Kumar P, Kale RK, Cowsik SM and Baquer N (2010). NEUROPROTECTIVE EFEFCTS OF ESTRADIOL ON ANTIOXIDANT STATUS, CALCIUM HOMEOSTASIS AND GLUCOSE TRANSPORTER IN AGING FEMALE RAT BRAIN. Front. Neurosci. Conference Abstract: Neuroinformatics 2010 . doi: 10.3389/conf.fnins.2010.13.00102 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 14 Jun 2010; Published Online: 14 Jun 2010. * Correspondence: Pardeep Kumar, Jawaharlal Nehru University,, School of Life Sciences, New Delhi, India, epardeep@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Pardeep Kumar R K Kale S M Cowsik N. Baquer Google Pardeep Kumar R K Kale S M Cowsik N. Baquer Google Scholar Pardeep Kumar R K Kale S M Cowsik N. Baquer PubMed Pardeep Kumar R K Kale S M Cowsik N. Baquer Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.