Abstract
Neuroprotective dose and safety profile of magnesium sulphate therapy in term neonates with perinatal asphyxia
Highlights
Perinatal asphyxia has become a major public health problem accounting for 9% of total under-5 mortality
The present study aims at establishing the optimum dose of magnesium sulphate infusion in term asphyxiated infants in the initial 48 hours of life to ensure a neuroprotective level of magnesium in that crucial period of brain injury
The present study was a prospective interventional study conducted in neonates with perinatal asphyxia delivered at Cheluvamba hospital attached to Mysore Medical College & Research Institute, Mysore, India from November 2011 to February 2012
Summary
Perinatal asphyxia has become a major public health problem accounting for 9% of total under-5 mortality. Background: To determine the effective dosage regimen and safety profile of intravenous magnesium sulphate as a neuroprotective agent for perinatal asphyxia in term neonates. Conclusion: Intravenous infusion of 3 doses of magnesium 250 mg/kg/dose in first 48 hrs after birth will ensure serum magnesium level in the neuroprotective range. This therapeutic dosage regimen has been found to have the best margin of safety profile in term asphyxiated infants. During hypoxia–ischemia, there is an increase in calcium influx into neuronal cells by stimulation of the NMDA (N-methyl-D-aspartate) receptors by excitotoxic aminoacids, mainly glutamate This increased intracellular calcium, interferes with many enzymatic reactions including the activation of lipases, proteases, endonucleases and phospholipases and the Manuscript received: 24th Jan 2016 Reviewed: 07th Feb 2016 Author Corrected; 17th Feb 2016 Accepted for Publication: 29th Feb 2016 formation of oxygen free radicals. The accumulation of cytosolic calcium after hypoxia–ischemia has detrimental effects on neuronal cells leading to irreversible brain damage [2]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Pediatric Review: International Journal of Pediatric Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
