Abstract
Introduction: Herpes zoster is a very common clinical condition caused by varicella zoster virus. Few studies are done covering the aspects like clinical presentation, epidemiology of this very common yet old disease. Objective: To find out clinical presentation, morphological pattern, evolution of herpes zoster along with its comorbid conditions. Materials and Methods: This was an analytical study conducted from June 2008 to December 2016 based on a preformed proforma carried out at skin department of rural based tertiary health care center. We have used Chi square test to analyze and tabulate the data obtained. It is an Observational and cross-sectional study. Results: Total 938 patients of herpes zoster were enrolled in the study. The incidence of herpes zoster amongst skin OPD cases was found to be 0.38%. The male to female ratio was found to be 1.37:1. Herpes zoster was mainly seen in the age group of 40-60 years (33.8%). The most common prodromal symptom seen was itching in 458 cases (41.5%). Most common presenting complaint was pain in 458 patients (41.50%). The past history of chicken pox was present in 22.7% patients. The commonest segment affected was thoracic in 374 cases (38.9%). Unidermatomal involvement was seen in 886(94.5%) cases, while multidermatomal involvement was seen in 43(4.6%) cases and disseminated in 9 (0.9%) cases. All the cases were screened for HIV, out of them; 40 (4.3%) were seropositive for HIV. Conclusion: Herpes zoster more commonly occurs in the age group of 40-60 years. Most common presenting complaint is burning type of pain. Most common dermatome involved is thoracic dermatome. Keywords: Herpes Zoster, Varicella zoster virus, Dermatome.
Highlights
Memory impairments are the most disabling features of many disorders, impairing the normal daily activities of the patients and profoundly affecting their families
Alzheimer’s disease (AD) is characterized by progressive loss of neurons mainly in hippocampus and cortex, which results in dysfunctions of cognition and emotion.[1]
transfer latency (TL) was noted after 45 min of administration of diazepam and after 24 hr.[21]
Summary
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder and there is no effective cure for this devastating disease till date. The cholinergic hypothesis of AD is well established,[6] which implied that the cholinergic system is important for learning and memory processes.[7] In clinical, donepezil (DON) and galantamine, which could elevate the level of acetylcholine (ACh), are used for AD therapy.[8,9] there are still some limitations, such as low efficacy, adverse effects for the long-term use[10]. MEMJCM-2 is a phytochemical based formulation comprising of Gangetin and pharmaceutical adjuvants. This suspension was prepared in our research laboratory using Gangetin. Other ingredients of the preparations were ascorbic acid, cardamom oil, methyl paraben, propyl paraben, propylene glycol, sodium carboxy methyl cellulose and purified water
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