Abstract
It has been reported that neuroinflammation is associated with the pathophysiology of many neurodegenerative disease, including Alzheimer’s disease (AD), and the treatments of anti-inflammatory drugs show the progress of these disease. In this study, we investigated the anti-inflammatory and neuroprotective effects of ethanol extracts of Citrus sunki peel(CPE) in BV2 microglia and HT22 neurons. It was found that CPE significantly suppressed LPS-induced NO production, pro-inflammatory cytokine IL-6 and proinflammatory enzyme Cyclooxygenase 2 (COX-2) in BV2 microglia. It also reduced LPS-induced NF-kB translocation and phosphorylation of MAP kinase (ERK, JNK, and p38). On the other hand, CPE significantly attenuated the neurotoxicity induced by BV2 microglia. Taken together, these results suggest that CPE has therapeutic potential against neurodegenerative diseases via regulation of microglial activation.
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