Neuroprotection of Multitargeted Phytochemicals against Alzheimer: A Desperate Need from Nature

Abstract

Background: Alzheimer’s disease (AD) is an incurable neurodegenerative disorder associated with dementia which leads to the alteration in the psychological and physiological functioning of the individual. From antiquity, medicinal plants serve as important sources of bioactive phytochemicals representing tremendous therapeutic potential. The unavoidable adverse effects associated with synthetic compounds trigger the exploration of new and safer substitutes for the treatment and management of disease conditions. Herbal medication proves to be an emerging and most promising alternative, which is expected to be a revolutionary approach in modern medicine for disease treatment. Objective: Several phytochemicals like resveratrol, curcumin, apigenin, docosahexaenoic acid, epigallocatechin gallate, and α-lipoic acid exhibit great potential in the prevention and management of AD. Their use might be a possible remedy and lead to a safe strategy to delay the onset of AD and slow the progression of this pervasive disorder. To determine the potential of these natural components as anti- AD, this review focuses on the updates on clinical studies and research. Methods: Extensive literature survey was carried out on natural multitargeted bioactive phytochemicals from various scientific databases like PubMed, Science Direct, Scopus, Clinicaltrails.gov, and many reputed foundations. Current prose emphasizes the identified bioactive compounds as anti-AD, which were reviewed with particular emphasis on their scientific impact and novelty. Results: These compounds diminish the pathophysiological aspects of AD; still, further studies are required to prove the safety and efficacy of these compounds in humans. Conclusion: This present review might help the researchers, academicians and industrialists in drug development as a new paradigm of drug discovery.