Neuroprotection in neurocritical care

Abstract

In intensive care medicine neuroprotection is understood mostly as various measures to avoid secondary brain damage after initial trauma, as in stroke, intracranial hemorrhage and resuscitation. Every brain trauma differs in the damage pattern and dynamics depending on the primary form of injury. Therefore, there are targeted treatment approaches depending on the pathophysiology of the medical condition. In addition, neuroprotective methods are desirable that are effective in the majority of patients with acute brain injury. In actual fact, in all forms of acute brain injury certain pathophysiological courses are encountered, which can lead to secondary brain damage depending on the intensity, e.g. reperfusion injury, damage to the blood-brain barrier and excitotoxicity. There is evidence to suggest that the creation of physiologically normal conditions leads to a favorable situation for the damaged brain. This article firstly describes the relevance of neuroprotective measures in neurocritical care medicine. Subsequently, general pathophysiological mechanisms in brain trauma are described. Following this, the pathophysiology and treatment options in brain pressure crises (reduction of intracranial pressure), anemia (transfusion management), hyperglycemia and hypoglycemia (adjustment of the blood sugar level) are dealt with. Finally, the use and benefits of therapeutic hypothermia are discussed. This has a special position as the only clinically effective individual measure for neuroprotection. The focus here is on the application following circulatory and cardiac arrest and resuscitation.