Neuroprotection by Glycyrrhiza Uralensis Extract in Anxiety Animal Model Involves the iNOS/Nrf2 Pathway

Abstract

Anxiety is a most common psychological disease, caused by stress. Many drugs for treated anxiety have various side effects and natural resources have a possibility as alternate material to eradicate these side effects. In this study is investigate inflammation modulate effects of Glycyrrhiza uralensis (GU) Extract in Forced Swimming Test (FST) induced depression rat model. 1 day after FST implemented during 15 min to training for rats, we measured FST and Y-maze test during each 6min, 3min to lock for acute effects of GU Extract, likewise measured behavior response with same method for chronic effects of GU Extract. We Received (May 07, 2015), Review Request(May 08, 2015), Review Result(May 26, 2015) Accepted(June 15, 2015), Published(August 31, 2015) 614-714 Dept. Clinical Laboratory Science, Dong-Eui Univ., Gaya 1-dong, Busanjin-gu, Busan, Korea email: excikind@naver.com 614-714 Dept. Clinical Laboratory Science, Dong-Eui Univ., Gaya 1-dong, Busanjin-gu, Busan, Korea email: rokmagnum@naver,com (Corresponding Author) 614-714 Dept. Clinical Laboratory Science, Dong-Eui Univ., Gaya 1-dong, Busanjin-gu, Busan, Korea email: kyhyun@deu.ac.kr Neuroprotection by Glycyrrhiza uralensis Extract in Anxiety animal Model Involves the iNOS/Nrf2 Pathway Copyright c 2015 HSST 156 orally administerd EU extract 100mg/kg and Sodium Tianeptine 10mg/kg. Researcher result showed oral administration of GUF Extracts significantly redused immobility time and increased total entries, total distance, down regulation of iNOS, Nrf2 expression in medulla oblongata and adrenal gland, anti-anxiety modulatory effect.