Neuroplasticity subserving the operation of brain–machine interfaces

Abstract

Neuroplasticity is key to the operation of brain machine interfaces (BMIs)—a direct communication pathway between the brain and a man-made computing device. Whereas exogenous BMIs that associate volitional control of brain activity with neurofeedback have been shown to induce long lasting plasticity, endogenous BMIs that use prolonged activity-dependent stimulation – and thus may curtail the time scale that governs natural sensorimotor integration loops – have been shown to induce short lasting plasticity. Here we summarize recent findings from studies using both categories of BMIs, and discuss the fundamental principles that may underlie their operation and the longevity of the plasticity they induce. We draw comparison to plasticity mechanisms known to mediate natural sensorimotor skill learning and discuss principles of homeostatic regulation that may constrain endogenous BMI effects in the adult mammalian brain. We propose that BMIs could be designed to facilitate structural and functional plasticity for the purpose of re-organization of target brain regions and directed augmentation of sensorimotor maps, and suggest possible avenues for future work to maximize their efficacy and viability in clinical applications.