Abstract
Motor unit number estimation (MUNE) techniques estimate the number of motor units innervating a single muscle or a group of muscles. As such, MUNE techniques are commonly used to quantify the loss of motor units in disease. MUNE requires obtaining and analysing neurophysiological recordings of compound muscle action potentials (CMAPs) evoked by stimulation of a peripheral nerve. Here, we describe a neurophysiological method that allows for the generation of stimulus–response curves that are achieved through increasing incremental electrical stimulation of the right sciatic nerve of mice and recording of the CMAP in the right gastrocnemius muscle. Performing this neurophysiological technique for subsequent MUNE analysis has vast implications for determining motor unit numbers where motor unit loss is thought to occur.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
