Abstract
BackgroundChronic obstructive pulmonary disease (COPD) is accompanied by substantial systemic dysregulations that comprise systemic inflammation and neurohormonal activation in addition to many neurological involvements, such as cerebrovascular diseases, polyneuropathies, motor neuron diseases, and cognitive impairment has been described in COPD patients. The aim of the current work was to detect the subclinical affection of the peripheral nervous system in patients with stable COPD.ResultsForty COPD patients and 30 subjects as healthy control were enrolled. All included subjects were submitted to complete medical history, clinical evaluations, investigations in the form of; arterial blood gases, spirometry, in addition to nerve conduction study. The patients with COPD were classified according to GOLD criteria for severity in grade I in 7.5% grade II in 62.5%, grade III in 20%, and grade IV in 10%. The results show a statistically significant increase in distal latency and a statistically significant decrease of amplitude and conduction velocity in patients with COPD when compared to the examined nerves of control group. The demyelinating nerve affection was the most common.ConclusionIn COPD patients the peripheral nervous system could be affected subclinically once the severity of COPD increased and the patient should be neurophysiologically observed for early recognition of peripheral nervous system affection.
Highlights
Chronic obstructive pulmonary disease (COPD) is defined as chronic inflammatory lung disease, characterized by progressive pulmonary destruction, shortness of breath, mucus production, and chronic coughing [1]
Forty patients with stable COPD in addition to 30 healthy subjects as a control were included in this study, the mean age of patients with stable COPD was 63.80 ± 2.13 years, whereas the mean age in the control group was 64.13 ± 1.94 years
Arterial blood gases besides the pulmonary function test showed a statistically significant decrease of pH, PaO2, SO2, FEV1, FEV1/forced vital capacity (FVC), and FVC% in the COPD group when compared to the control group
Summary
COPD is defined as chronic inflammatory lung disease, characterized by progressive pulmonary destruction, shortness of breath, mucus production, and chronic coughing [1]. Neurohormonal activation, Hypoxemia, and hypercapnia, are the chief mechanisms of the pathophysiology of systemic affections [4]. Many neurological affections such as polyneuropathies, motor neuron diseases, cerebrovascular diseases, and cognitive impairment have been described in patients with COPD [5,6,7]. The aim of the present study was to detect the subclinical affection of the peripheral nervous system in patients with stable COPD. Chronic obstructive pulmonary disease (COPD) is accompanied by substantial systemic dysregulations that comprise systemic inflammation and neurohormonal activation in addition to many neurological involvements, such as cerebrovascular diseases, polyneuropathies, motor neuron diseases, and cognitive impairment has been described in COPD patients.
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