Abstract
BackgroundIdiopathic intracranial hypertension (IIH) is a disorder with increased intracranial pressure of obscure cause. Patients with IIH may suffer from difficulty in thinking or concentrating. This work aimed at highlighting the neurophysiologic suggestions of cognitive impairment in IIH patients.MethodsTwenty patients with IIH—and a similar number of matched control subjects—were examined in this case–control study. The P300 and contingent negative variation (CNV) were performed. Results from both groups were compared.ResultsThere were significant lower means of P300 amplitude and CNV amplitude (early and late response) in patients than in controls. Also, there were significant delayed latencies of P300 and CNV in patients than in normal control subjects. Finally, P300 latency was correlated to mini-mental state examination.ConclusionsWe concluded that cognitive affection in IIH is well appreciated at neurophysiologic levels and is related to clinical inputs. We are providing a suggestion of the significant relation between clinical screening (i.e., mini-mental state examination) and NP screening (i.e., P300) of cognitive functions.
Highlights
Idiopathic intracranial hypertension (IIH) is a disorder with increased intracranial pressure of obscure cause
Eleven (55%) patients had severe headache, with only nine (45%) patients having mild to moderate headache
In conclusion, our study is suggesting that the mini-mental state examination (MMSE), used for basic assessment of cognitive functions, is of strong NP basis
Summary
Idiopathic intracranial hypertension (IIH) is a disorder with increased intracranial pressure of obscure cause. This work aimed at highlighting the neurophysiologic suggestions of cognitive impairment in IIH patients. The P300 and contingent negative variation (CNV) were performed. Idiopathic intracranial hypertension (IIH) is a disorder with increased intracranial pressure with no clinical, laboratory, or radiological evidence of intracranial pathology on conventional imaging (Wall 2010). The event-related potential (ERP), P300, is involved in cognitive processing (Thakur et al 2011), whereas the contingent negative variation (CNV) is another ERP that is speculated to show awareness, attention, decision-making, Aim of work The hypothesis of impaired cognition in IIH patients was adopted. Neurophysiologic (NP) tests were used as tools to screen for the presence/absence of impaired cognition in such patients
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