Abstract
Recent studies demonstrate that anesthesia-induced loss of consciousness is a cascade process occurring in hierarchical sequences, including brainstem depression-reduced the influences of the ascending reticular activating system on thalamus and cortex,depression of mesolimbic-dorsolateral prefrontal cortex interactions and thalamic-thalamocortical reverberations, interruption of prefrontal-parietal transactions critical for perception, inhibition of prefrontal cortex, etc. Among them thalamus plays a central role. Anesthesia-induced loss of consciousness can be accomplished by inhibiting any taches of the cascade and the corresponding couples and integration. Key words: anesthesia; loss of consciousness; neurophysiology
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