Abstract
Neurophotonics involves optical techniques for brain imaging - in health and disease. This review will present two technologies, laser speckle imaging and photoacoustic imaging. Laser speckle contrast can be correlated with blood flow and therefore can be used for imaging brain blood flow and microcirculation in applications such as stroke. Further, speckle imaging can be combined with electrophysiological monitoring. Photoacoustic imaging is a more recent technique suitable for imaging deeper into brain tissue, and for studying cortical structures and function in applications such as angiogenesis accompanying tumors. Further improvements in contrast and specificity may come from using nanoparticles. These technologies are advancing rapidty towards clinical applications.
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