Abstract

1. 1. Exogenously applied neuropharmacological agents profoundly affected the swimming behaviour and survivorship of Cercaria caribbea LXXI. 2. 2. Propranolol (1.1–40 μM), haloperidol (0.66–0.133 mM) and physostigmine (0.08–2.5 mM) were the most potent reducers of population half-life (T 50). 3. 3. Some drugs (e.g. reserpine) produced apparent osmotic disturbances leading to shortened life span. 4. 4. Serotonin had the greatest excitatory effect on swimming and on the electrical activity, increasing the amplitude and frequency of spike discharge. Physostigmine most effectively reduced both parameters. 5. 5. Neuromuscular control of swimming may involve central excitatory nicotinic (cholinergic) and beta adrenergic influences, inhibitory muscarinic (cholinergic) and dopaminergic influences; and local excitatory muscarinic and serotonergic influences.

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