Abstract
In the past 20 years, research into biochemical determinants of disturbed behavior has focused mainly on the central monoamines (MA). Other central transmitters either did not fulfill these criteria, or did so only to a partial extent. An example is acetylcholine. The discovery of the neuropeptides was of importance to biological psychiatry for two reasons. The first is a general reason: neuropeptides represent a new principle in neurobiology, that of hormone-like compounds produced in the brain, whose target is the brain. The second is a specific biological psychiatric reason: the neuropeptides have added a new dimension to human brain and behavior research, supplementary to the MA dimension. This chapter discusses the relation between neuropeptide and MA systems.
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