Abstract
mRNA encoding the human NPY Y 1 and NPY Y 2 receptors were detected in cerebral, meningeal, and coronary arteries using reverse transcriptase–polymerase chain reaction (RT–PCR). In addition, the trigeminal and superior cervical ganglia were positive for both receptors. In some arteries and in SK-N-MC cells only mRNA encoding the NPY Y 1 was detected. Besides the expected NPY Y 1 PCR products, an additional 97 bp longer amplicon originating from an alternative splicing event was found in most tissues studied. Antibodies directed against the NPY Y 1 receptor revealed immunostaining mainly in the smooth muscle layer of blood vessels whereas antibodies against the NPY Y 2 receptor showed immunostaining in nerve cell bodies.
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