Abstract
The neuropeptide research in the eye is the main topic of our scientific group in Innsbruck. Most of the neuropeptides have been discovered more than 30 years ago and the presence and distribution of some of them has been explored in the eye in the 80´s mainly by Richard Stone. This concerns particularly substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY). Whereas SP and CGRP have been found to be constituents of the sensory innervation of the eye, VIP is present in the parasympathetic and NPY in the sympathetic innervation of the eye. These results have been reviewed in 1987 in “Experientia”. In the retina, the typical neuropeptide localization are amacrine cells in the proximal inner nuclear layer and displaced amacrine cells in the ganglion cell layer but some of them are also present in ganglion cells.
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