Abstract
Twenty adult mentally retarded men were randomly assigned to receive MSH/ACTH 4–10 or a vehicle control solution in a double blind procedure. After an intravenous injection the subjects were presentedd with an orienting sequence and a series of behavioral tests. Treatment with the peptide resulted in a significant decelerative heart rate response during the test stimulus of the orienting sequence. Improved performance of the intradimensional and extradimensional shift of a visual discrimination procedure was significant for subjects receiving MSH/ACTH 4–10. The pattern of response on the subproblem analysis of the extradimensional shift reflected greater dimensional attention in the subjects treated with the peptide. Attentive subjects given MSH/ACTH 4–10 evidenced significant improvement on a rhythm matching test, a test of spatial localization and a visual retention test. The data were interpreted as indicating that the peptide resulted in improved attention of stimulus processing. It was speculated that MSH/ACTH 4–10 may be uniquely coded for perceptual/ attentional functioning and may be useful as a treatment for disorders of attention.
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