Abstract
BackgroundWhile most neuropathologic studies focus on regions involved in behavioral abnormalities in autism, it is also important to identify whether areas that appear functionally normal are devoid of pathologic alterations. In this study we analyzed the posteroinferior occipitotemporal gyrus, an extrastriate area not considered to be affected in autism. This area borders the fusiform gyrus, which is known to exhibit functional and cellular abnormalities in autism.FindingsNo studies have implicated posteroinferior occipitotemporal gyrus dysfunction in autism, leading us to hypothesize that neuropathology would not occur in this area. We indeed observed no significant differences in pyramidal neuron number or size in layers III, V, and VI in seven pairs of autism and controls.ConclusionsThese findings are consistent with the hypothesis that neuropathology is unique to areas involved in stereotypies and social and emotional behaviors, and support the specificity of the localization of pathology in the fusiform gyrus.
Highlights
While most neuropathologic studies focus on regions involved in behavioral abnormalities in autism, it is important to identify whether areas that appear functionally normal are devoid of pathologic alterations
These findings are consistent with the hypothesis that neuropathology is unique to areas involved in stereotypies and social and emotional behaviors, and support the specificity of the localization of pathology in the fusiform gyrus
The purpose of this study was to identify whether an area with little-known relevance to autism, the posteroinferior occipitotemporal gyrus (PIOTG), exhibited neuropathologic features present in areas associated with the behavioral abnormalities of autism
Summary
The purpose of this study was to identify whether an area with little-known relevance to autism, the PIOTG, exhibited neuropathologic features present in areas associated with the behavioral abnormalities of autism
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