Neuropathology of neurocutaneous melanosis: histological foci of melanotic neurones and glia may be undetectable on MRI.

Veronica A Kinsler,Glenn W Anderson,William Harkness,Neil J Sebire,Simon M L Paine,Wui K Chong,D Saraji Wijesekara,Sarah E Aylett,Thomas S Jacques

doi:10.1007/s00401-012-0945-0

Veronica A Kinsler, Glenn W Anderson + Show 7 more

Open Access

https://doi.org/10.1007/s00401-012-0945-0

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Abstract

Neuropathology of neurocutaneous melanosis: histological foci of melanotic neurones and glia may be undetectable on MRI.

Highlights

Neurocutaneous melanosis (NCM) is the association of congenital melanocytic naevi (CMN) and melanotic lesions in the central nervous system
With the recognition of a characteristic MR signal for melanin [1], it is recognised that a significant proportion of individuals with CMN have CNS
Intra-parenchymal melanosis on magnetic resonance imaging (MRI) is associated with an increased risk of neurological complications [9, 12, 14, 18], a significant proportion of children with CMN have abnormal clinical neurology with normal scans [4, 14, 18]

Summary

Introduction

Neurocutaneous melanosis (NCM) is the association of congenital melanocytic naevi (CMN) and melanotic lesions in the central nervous system. Kinsler Department of Paediatric Dermatology, Great Ormond Street Hospital for Children NHS Trust, London, UK S. Jacques Department of Histopathology, Great Ormond Street Hospital for Children NHS Trust, London, UK Chong Department of Neuroradiology, Great Ormond Street Hospital for Children NHS Trust, London, UK

Results

Conclusion