Abstract
Intrinsic innervation changes in chronic chagasic cardiopathy long have been regarded as pathognomonic to the disease clinicopathologically and acritically ascribed to incurable “neuronal depletion.” This allegedly diffuse, frequent, and devastating damage to parasympathetic cardiac ganglia was absent in the seven cases we examined and was not demonstrated by reliable neuropathologic diagnosis in former studies from the literature, where the evidence of Terplan nodules, the very hallmark of autonomic neuronal loss, had been lamentably disregarded. Thus, dysautonomic manifestations in chronic chagasic cardiopathy should be attributed to the frequent and widespread finding of neuritic involvement in the severe (auto-) immune fibrosing myocarditis peculiar to the disease.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.