Abstract
We can identify a distinct group of neoplasias in patients with chronic focal epilepsies. These tumors often present with an unusual histomorphological spectrum and were designated as long-term epilepsy-associated tumors (LEATs). Surgical tumor specimens open the possibility to address the origin and epileptogenicity of LEATs (i.e., gangliogliomas and dysembryoplastic neuroepithelial tumors) neuropathologically as well as neurobiologically. Intriguingly, most studies failed to identify common tumor-associated genetic aberrations in this material. In contrast, neurodevelopmentally regulated genes – e.g., for elements in the insulin growth factor receptor or reelin-signaling pathways – are likely to play key roles. Research analysis of LEAT, therefore, opens new avenues for understanding brain development under physiological as well as pathophysiological conditions.
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