Abstract
Malignant human gliomas corresponding to grade III and IV are anaplastic ependymomas, anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic mixed gliomas and the glioblastoma group (WHO classification, 43). These high-grade gliomas are characterized by an increased rate of cell proliferation and by special regressive changes, such as mucoid and fatty degeneration, cyst formation and in particular by tumor necrobiosis and/or necrosis (33, 46). Size and kind of necroses, however, vary with regard to tumor type and tumor grade. Whereas anaplastic gliomas contain by definition multiple and sometimes abundant necrotic foci, in glioblastomas microscopic necroses of the pseudo palisading type occur as well as macroscopically visible large areas of multicentric necroses.
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