Abstract
We report here several neuropathological alterations in the host brain one year after the placement of intrahippocampal neural allografts of cholinergic-rich basal forebrain tissue in fimbria-fornix lesioned rats. The immunological reaction against the allografts had resulted in damage to the host tissue surrounding the graft, specifically to the host cerebral cortex and the corpus callosum. In the host hippocampus, there was damage to the CA1 cell layer and abnormal neurofilament accumulations in perikarya and in axonal swellings were revealed by RT97 immunohistochemistry. These changes were not found within the grafts, which appeared relatively healthy. F344 rats received fimbria-fornix lesions and PVG foetal basal forebrain tissue into the host hippocampus (bilateral). These rats also received injections of irradiated PVG splenocytes (s.c.) 10-11 mo. later, in an attempt to cause an immunological rejection of the PVG neural grafts. The grafts were examined immunohistochemically 12 mo. post-grafting with various markers (results presented previously /5/. This
Highlights
F344 rats received fimbria-fornix lesions and PVG foetal basal forebrain tissue into the host hippocampus
Cell bodies and axonal swellings were stained with the RT97 antibody in the host hippoeampi of the transplanted rats
Numerous stained cell bodies and axonal swellings were found almost everywhere within the hippocampus of one particular transplanted rat, but only 2-3 were observed in the thalamus and cortex and no such abnormal structures were observed in the transplants themselves
Summary
F344 rats received fimbria-fornix lesions and PVG foetal basal forebrain tissue into the host hippocampus (bilateral). Cell bodies and axonal swellings were stained with the RT97 antibody in the host hippoeampi of the transplanted rats. Numerous stained cell bodies and axonal swellings were found almost everywhere within the hippocampus of one particular transplanted rat, but only 2-3 were observed in the thalamus and cortex and no such abnormal structures were observed in the transplants themselves.
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