Abstract
Background: The pathophysiology of the Postural Tachycardia Syndrome (POTS) remains poorly understood. It has been suggested that POTS may represent a heterogeneous condition of different phenotypic and pathophysiologic subtypes. Two well-defined phenotypes are neuropathic POTS (with findings of a limited autonomic neuropathy) and hyperadrenergic POTS (with features of sympathetic hyperactivity). We sought to evaluate and compare cardiovascular parameters of patients fulfilling previously described definitions for these subtypes and normal controls in the time and frequency domain.
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