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Abstract
Neuropathic pain is very often the earliest symptom of Fabry disease. Episodes of severe burning pain may occur from early childhood, typically in the feet and hands. These episodes are usually triggered by febrile infections, heat or cold exposure, physical exertion, or emotional stress and are known as “Fabry crises.” Often, the pain experienced by these children is misinterpreted as a symptom of infection rather than being recognized as a manifestation of Fabry disease. About 75% of adults with Fabry disease experience pain.
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