Abstract
Muscular dysgenic (mdg/mdg) myotubes cultured alone do not contract. Glucosephosphate isomerase (GPI-1) isozymes were analyzed to determine the final genotype of cultured dysgenic (mdg/mdg, gpi-1a/a) myotubes to which normal embryonic spinal cord and limb cells (CBA/J +/+, gpi-1b/b) had been added. Although both myoblast and spinal cord cell additions caused induction of spontaneous contractions, only myoblasts fused with the myotubes to create functional heterokaryons. Spinal cord cells did not fuse with dysgenic myotubes, but formed functional synapses.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
