Abstract
Neuronal Plasticity in the Entorhinal Cortex
Highlights
The significance of plasticity in the entorhinal cortex (EC) is best understood within the context provided by anatomical knowledge of the extrinsic and intrinsic connectivity of this area
The EC is tightly intertwined with circuitries of the hippocampal formation and other cortical areas, and its particular contributions to sensory processing, learning, memory, and motor behavior have been difficult to define
Hernandez et al have found that prenatal malnutrition has lasting effects on the capacity of the EC to express long-term synaptic potentiation (LTP), and it is possible that this reduced plasticity may contribute to deficits in learning and memory in the adult
Summary
The significance of plasticity in the EC is best understood within the context provided by anatomical knowledge of the extrinsic and intrinsic connectivity of this area. There has been burgeoning interest in synaptic plasticity at entorhinal synapses in relationship with learning and memory functions of limbic structures.
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