Abstract
Neuronal mechanisms of epileptogenesis
Highlights
The primary purpose of this topic is to collect scientific contributions providing novel insights in the cellular and molecular mechanisms of epileptogenesis as potential targets for innovative therapeutic approaches aimed at preventing the chronic epileptic disorder
Genetic mutations enhancing structural and functional alterations of key proteins including pre-synaptic complexes (Toader et al, 2013) and potassium channels (D’Adamo et al, 2013) are related to the occurrence of epileptic disorders. With these findings obtained in genetic animal models of epilepsy, studies conducted in animal models of acquired epilepsy addressed the critical role of vesicular neurotransmitters transporters (VNTs) (Van Liefferinge et al, 2013) and non-neuronal potassium channel (Kir4.1) (Nagao et al, 2013) expression during epileptogenesis
Temporal Lobe Epilepsy (TLE) is the most common form of refractory epileptic disorder often related to childhood seizures
Summary
The primary purpose of this topic is to collect scientific contributions providing novel insights in the cellular and molecular mechanisms of epileptogenesis as potential targets for innovative therapeutic approaches aimed at preventing the chronic epileptic disorder. With these findings obtained in genetic animal models of epilepsy, studies conducted in animal models of acquired epilepsy addressed the critical role of vesicular neurotransmitters transporters (VNTs) (Van Liefferinge et al, 2013) and non-neuronal potassium channel (Kir4.1) (Nagao et al, 2013) expression during epileptogenesis. Temporal Lobe Epilepsy (TLE) is the most common form of refractory epileptic disorder often related to childhood seizures.
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