Abstract

Autonomic Nervous System In article number 2100808 by Yan Zhang, Hui Xie, and co-workers, osteocyte neuropeptide Y (NPY)-dependent neuronal control of bone marrow mesenchymal stem/stromal cell (BMSC) fate decision is found. Osteocyte NPY promotes bone marrow adipogenesis at the expense of osteogenesis by BMSC. Osteocyte NPY production is controlled by autonomic nervous system (ANS). γ-Oryzanol attenuates ANS dysregulation, NPY overproduction, and bone-fat imbalance induced by aging and estrogen deficiency.

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