Abstract
Aim: Neuronal guidance cues (NGCs) are known for controlling neuronal migration and vascular patterning through a complex interplay of signals. It has been shown that NGCs and their receptors play an important role in the regulation of the adhesion of monocytes to the vascular endothelium and their subsequent proatherogenic actions. However, the role of NGCs in human atherosclerosis is not well studied.Because we know that monocyte adhesion and the vascular endothelium permeability play an important role in the atherosclerotic process, we hypothesize that a dysfunctional NGC pathway contribute to this in patients with premature atherosclerosis (PAS) and no cardiovascular risk factors.
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