Neuronal depletion of omega-3 fatty acids induces flax seed dietary self-selection in the rat

Abstract

The impact of essential dietary fatty acid deficiency on self-selection of fatty acid enriched foods is little studied in spite of widespread health promotion claims for fatty acid supplemented diets. Accordingly, the present studies investigated the consequences of consumption over four weeks of omega-3 fatty acid replete and deficient diets on dietary fatty acid self-selection and brain lipid composition in rats. Dietary omega-3 fatty acid deficiency produced correspondingly low levels (50–55% decrease) of omega-3 fatty acids in the forebrain relative to rats consuming an omega-3 fatty acid replete diet. The state of omega-3 fatty acid deficiency generated a robust preference for consumption of an omega-3 fatty acid replete diet. Moreover, omega-3 fatty acid self-selection developed slowly and was not present in rats maintained on laboratory chow diet suggesting that post-ingestive nutritional cues, rather than taste, odor or texture cues, were employed in guiding the preference for the omega-3 fatty acid enriched diet. These results provide evidence for the ability of rats with declining brain levels of omega-3 fatty acids to detect a dietary deficiency of this essential class of lipids and to identify and consume a food source capable of restoring fatty acid repletion.