Abstract
In this short review, we present and discuss evidence that there may be important parallels between cell death during development and neurodegenerative diseases. The finding that bcl-2 can protect neurons from death during development and in pathology speaks in favor of common mechanisms. In addition, the recent finding that the apolipoprotein E (ApoE) gene is associated with Alzheimer's disease, and that ApoE plays a role in neurite outgrowth, in vitro, supports the hypothesis that inappropriate interactions between growing or remodeling axons and their target cells can trigger neuronal death in adults as they do during development.
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