Abstract

We thank J.-F. Brunet, P. G. H. Clarke, O. deLapeyriere, P. Golstein, J.-C. Martinou, C. Mulle, and R. W. Oppenheim for thoughtful comments on the manuscript and C. Waldmann for artwork. In a short review such as this, it is not possible to establish precedence for all ideas or mechanisms, many of which originate from (or are still confined to) studies outside the nervous system. Wherever possible, we have therefore illustrated each topic by citing recent articles involving neurons. We refer the interested reader to the reference lists of those articles, or of the many excellent reviews we have cited, for more ample details. Studies from our laboratory were supported by INSERM, CNRS, Association Francaise contre les Myopathies (AFM), Institut pour la Recherche sur la Moelle Epiniere (IRME), and European Commission BIO4 contract CT960433.

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