Abstract
The effect of the selective μ-opioid receptor agonist Tyr-Pro- N-MePhe- d-Pro-NH 2 (PL-017) on tonic activity and temperature sensitivity of neurons in the preoptic area/anterior hypothalamus (PO/AH) has been examined in rat brain slices using extracellular recordings. The tonic activity of both warm-sensitive and temperature-insensitive neurons was inhibited in a dose-dependent manner by superfusion with the μ-agonist (0.5–100 nM). The temperature sensitivity was selectively decreased in warm-sensitive neurons in concentrations up to 10 nM. Only in the high concentration of 100 nM did the μ-agonist reduce the temperature coefficient of both types of neurons. Pretreatment with equimolar concentrations of the μ-antagonist d-Phe-Cys-Tyr- d-Trp-Orn-Thr-Pen-Thr-NH 2 (CTOP) prevented the effects of the μ-agonist (0.5–10 nM) on tonic activity as well as temperature sensitivity. The results suggest that a specific change of the temperature sensitivity of PO/AH neurons is involved in the hyperthermia induced by μ-agonists in rats.
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