Abstract
Protective effect of quercetin on weight drop injury model-induced neuroinflammation alterations in brain of miceHmangte Hitler Kom, Mesram Nageshwar, Kota Srilatha, Karnati Pratap Reddy
Highlights
Neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson disease (PD) are common among the Olatunji et al / Journal of Applied Pharmaceutical Science 7 (12); 2017: 156-162The contribution of the inflammatory component of diverse disorders to disease progression has led to novel attempts aimed at discovering ways to attenuate inflammation therapeutically (Nathan, 2002)
This activity could be attributed to their antioxidant potential as evidenced from their inhibitory effect on MDA and increased CAT activity and GSH
There was significant increase (p < 0.01) in the level of MDA both in the brain tissue and blood serum of the untreated LPS-induced mice when compared with the vehicle group
Summary
Neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson disease (PD) are common among the Olatunji et al / Journal of Applied Pharmaceutical Science 7 (12); 2017: 156-162The contribution of the inflammatory component of diverse disorders to disease progression has led to novel attempts aimed at discovering ways to attenuate inflammation therapeutically (Nathan, 2002). Numerous ethnomedicinal plants have been used to treat several cognitive disorders including Alzheimer's disease They act as excellent antioxidants, anti-inflammatory mediators, cholinesterase and β-secretase inhibitors. Aim: The present study sought to evaluate the effect of three medicinal plants (Bacopa floribunda (R.Br)Wettst, Scoparia dulcis L and Cordia millenii Bak.) locally used for memory enhancement on neuronal histology and antioxidant status against Lipopolysaccharide induced neuronal damage in mice. Results: Oral administration of LPS induced neuronal damage through cell death as evidenced by the histological analysis and altered brain antioxidant status in mice. The plant extracts were able to prevent such neuronal alterations and restored the antioxidant status when compared to the LPS induced neuronal damage in mice. Neural damage was prevented by the extracts This activity could be attributed to their antioxidant potential as evidenced from their inhibitory effect on MDA and increased CAT activity and GSH. Other possible mechanisms of action against neuronal damage need to be assessed to further justify their use traditionally in the treatment/management of neurodegenerative diseases
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