Abstract
In adult mammals trauma to the central nervous system (CNS) results in extensive neuronal death with virtually no regeneration or recovery of function. Regeneration in the peripheral nervous system (PNS) of the same animals is robust and functional recovery more or less successful. The possibility that this descrepancy results entirely from differences in the capacities for nerve fiber growth of CNS vs PNS neurons is inconsistent with studies showing that CNS neurons will regenerate extensively into peripheral nerve grafts (1). In fact, the environment of the CNS appears inhospitable for growth of peripheral (2) or central neurons. One well-known external effector of nerve fiber growth is the soluble protein (Mr 26,500) Nerve Growth Factor (reviewed in 3). Other less well-characterized trophic agents have been reported (reviewed in 4).
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