Neuron Specific Enolase in Relation to Chitotriosidase and Heat Shock Protein 72: A Network of Integrated Predictive Biomarkers in Preeclampsia and Eclampsia

Abstract

Background: Preeclampsia and eclampsia are life-threatening conditions with increasing incidence. Since, Neuron specific enolase (NSE) is a vital biomarker for neuronal damage, our study aimed to investigate its role in relation to macrophage activation, angiogenesis, heat shock protein 72 and antioxidant biomarkers in preeclampsia and eclampsia patients. Methods: This study included 45 pregnant women; divided into 3 groups. Group I included 15 healthy pregnant women (control group), Group II included 15 preeclampsia patients and Group III included 15 eclampsia patients. They were subjected to measurement of plasma of NSE, insulin growth factor-1 (IGF-1), nitric oxide (NO), heat shock protein 72 (HSP72) levels and chitotriosidase activity in addition to serum paraoxonase activity. Results: The study showed significant increased levels of NSE, IGF-1, HSP72, and chitotriosidase activity in group II and III when compared to control group with the highest levels in group III. On the other hand, it showed significant decrease in NO level and paraoxonase activity in group II and III when compared to control group with lowest level in group III. Conclusion: Based on our findings, NSE can be used as a reliable biomarker to predict the outcome of preeclampsia and early prediction of eclapmsia to avoid serious complications.