Neuromuscular junction disorders (NMJ) P-NJ001. Quality of life comparison between myasthenia gravis with plasma exchange and myasthenia gravis without plasma exchange

Abstract

Introduction . Myasthenia gravis (MG) is an autoimmune disease affecting neuromuscular junction of skeletal muscle. Plasma Exchange (PE) is one of the treatments of choice in severe MG. Myasthenia gravis with or without PE can weaken patient motor function and furthermore produce negative impact on quality of life. Aim: To investigate Quality of Life difference between MG with PE and without PE. Methods . Twenty one adults with MG in outpatient clinic Neurology Department of Dr. Sardjito General Hospital, Yogyakarta, Indonesia from September to November 2019 were recruited and divided into two groups according to PE treatment. Quality of Life was evaluated with the Short-Form 36-item Health Survey (SF-36). Results . There were statistically significant differences in physical functioning scale (47.73 + 11.04 vs 74.50 + 10.39; p = 0.0001) and in role physical scale (54.54 + 24.54 vs 82.50 + 16.87; p = 0.007) between MG with PE group and MG without PE group. There were no statistically significant differences in bodily pain, general health, vitality, social functioning, role emotional, and mental health scale. Conclusion . This study demonstrated that quality of life in physical functioning and role physical scale was significantly reduced in MG with PE treatment. Keywords . Myasthenia Gravis, Quality of Life, SF-36, Plasma Exchange