Abstract
Neuromuscular blocking agents (NMBAs) are a class of drugs used to produce skeletal muscle relaxation and paralysis most commonly to facilitate surgical and diagnostic procedure in anesthetized animals. A clear understanding of the physiologic events occurring at the neuromuscular junction is essential, as it is the site of action for drugs used to prevent muscular contraction. NMBAs can be broadly classified into two categories based on their mechanism of action: depolarizing NMBAs and nondepolarizing NMBAs. Currently, the most commonly used nondepolarizing NMBAs are atracurium, cis-atracurium, vecuronium, and rocuronium. They can be divided into two categories based on their chemical structure, benzylisoquinolines and aminosteroids. NMBAs are a unique class of drugs that are helpful in providing profound muscle relaxation and immobilization of patients during anesthesia. Use of NMBAs requires an ability to provide mechanical ventilation and monitoring of neuromuscular function.
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