Abstract
The effect of the antidepressive drug amitriptyline on neuromuscular transmission was studied on frog sartorius neuromuscular preparation, using intracellular recording techniques. The amplitude of the end plate potential is greatly reduced by amitriptyline (2 μg/ml). The amplitude of the miniature end plate potentials is only slightly affected by the drug. Hence it is concluded that the inhibitory effect of amitriptyline on neuromuscular transmission is due to a decrease in the amount of transmitter liberated from the presynaptic nerve terminals.
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