Neuromuscular and perceptual mechanisms of fatigue accompanying task failure in response to moderate-, heavy-, severe-, and extreme-intensity cycling

Abstract

A comprehensive characterization of neuromuscular and perceptual mechanisms of fatigue at task failure following exercise across the entire intensity spectrum is lacking. This study evaluated the extent of peripheral and central fatigue, and corresponding perceptual attributes, at task failure following cycling within the moderate-(MOD), heavy-(HVY), severe-(SVR), and extreme-(EXT) intensity domains. After a ramp-incremental test, 11 young males performed four constant-power output trials to the limit of tolerance (Tlim) at 4 distinct domain-specific workloads. These trials were preceded and followed by 5-s knee-extension maximal voluntary contractions (MVCs) and femoral nerve electrical stimuli to quantify peripheral and central fatigue. In addition, perceptual measures including ratings of global fatigue, legs pain, dyspnea, and perceived effort (RPE) were also collected. At Tlim, reductions in MVC were independent of intensity (P > 0.05). However, peripheral fatigue was greater following EXT and SVR and progressively, but distinctively, lower following HVY and MOD (P < 0.05). Central fatigue was similar after SVR, HVY, and MOD, but absent after EXT (P < 0.05). At Tlim, subjective ratings of global fatigue were progressively higher with lower exercise intensities, whereas ratings of legs pain and dyspnea were progressively higher with higher exercise intensities. On the other hand, RPE was maximal following HVY, SVR, and EXT, but not MOD. The findings demonstrate that at Tlim, the extent of peripheral fatigue is highly domain-specific, whereas the extent of central fatigue is not. Sensations such as fatigue, pain, and dyspnea may integrate with mechanisms of sense of effort to determine task failure in a manner specific to each intensity domain.NEW & NOTEWORTHY Together with other physiological responses, the neuromuscular fatigue mechanisms, and related perceptual responses, accompanying task failure are suggested to be dependent on the intensity domain within which exercise is sustained. Here, we show that peripheral fatigue demonstrates a high domain specificity, whereas such specificity is absent for central fatigue. Sensations of fatigue, pain, and breathlessness demonstrated intensity domain specificity and might have contributed to reaching maximal levels of RPE and, thus, task failure.