Neuromotor and cognitive development of borns after the transfer of vitrified-warmed embryos derived from intracytoplasmic sperm injection using vitrified-thawed oocytes

Abstract

ObjectiveTo report the behavior and development of borns derived from vitrified-warmed embryos originated from the intracytoplasmic sperm injection (ICSI) of vitrified-warmed oocytes.DesignProspective, observational and analytic study.Materials and MethodsProspective study performed from August 2008 through October 2012. Were analyzed six newborns from assisted reproduction techniques. We included 4 couples requiring IVF. In all, were used intracytoplasmic sperm injection using vitrified-thawed oocytes. Two embryos for couple were transferred in a fresh cycle resulting in no pregnancy; supplementary embryos were vitrified. In a consecutive natural cycle two vitrified embryos were warmed and survived with 100% of intact blastomeres and good quality morphology. Both were transferred, resulting in a twin pregnancy and 4 single pregnancy. After birth, children were evaluated with Apgar, Brazelton and Bayli Score.ResultsAll our patients had a successful pregnancy and delivered healthy childrens. After birth, children were assessed at 0, 6, 12 and 18 months with Apgar, Brazelton and Bayli Score. Children's growth and intellectual development were the expected according to their age. Today, after two years of follow up, children have neuromotor and cognitive development according to age-expected.ConclusionFrom our experience, it can be said that children born from artificial reproduction treatments and that overwent vitrification procedures, have a normal medical, psychological and intellectual development according to children's age. The embryo and oocyte vitrification is a successful technique, and no negative effect had been found on assisted conception on developing human brain. ObjectiveTo report the behavior and development of borns derived from vitrified-warmed embryos originated from the intracytoplasmic sperm injection (ICSI) of vitrified-warmed oocytes. To report the behavior and development of borns derived from vitrified-warmed embryos originated from the intracytoplasmic sperm injection (ICSI) of vitrified-warmed oocytes. DesignProspective, observational and analytic study. Prospective, observational and analytic study. Materials and MethodsProspective study performed from August 2008 through October 2012. Were analyzed six newborns from assisted reproduction techniques. We included 4 couples requiring IVF. In all, were used intracytoplasmic sperm injection using vitrified-thawed oocytes. Two embryos for couple were transferred in a fresh cycle resulting in no pregnancy; supplementary embryos were vitrified. In a consecutive natural cycle two vitrified embryos were warmed and survived with 100% of intact blastomeres and good quality morphology. Both were transferred, resulting in a twin pregnancy and 4 single pregnancy. After birth, children were evaluated with Apgar, Brazelton and Bayli Score. Prospective study performed from August 2008 through October 2012. Were analyzed six newborns from assisted reproduction techniques. We included 4 couples requiring IVF. In all, were used intracytoplasmic sperm injection using vitrified-thawed oocytes. Two embryos for couple were transferred in a fresh cycle resulting in no pregnancy; supplementary embryos were vitrified. In a consecutive natural cycle two vitrified embryos were warmed and survived with 100% of intact blastomeres and good quality morphology. Both were transferred, resulting in a twin pregnancy and 4 single pregnancy. After birth, children were evaluated with Apgar, Brazelton and Bayli Score. ResultsAll our patients had a successful pregnancy and delivered healthy childrens. After birth, children were assessed at 0, 6, 12 and 18 months with Apgar, Brazelton and Bayli Score. Children's growth and intellectual development were the expected according to their age. Today, after two years of follow up, children have neuromotor and cognitive development according to age-expected. All our patients had a successful pregnancy and delivered healthy childrens. After birth, children were assessed at 0, 6, 12 and 18 months with Apgar, Brazelton and Bayli Score. Children's growth and intellectual development were the expected according to their age. Today, after two years of follow up, children have neuromotor and cognitive development according to age-expected. ConclusionFrom our experience, it can be said that children born from artificial reproduction treatments and that overwent vitrification procedures, have a normal medical, psychological and intellectual development according to children's age. The embryo and oocyte vitrification is a successful technique, and no negative effect had been found on assisted conception on developing human brain. From our experience, it can be said that children born from artificial reproduction treatments and that overwent vitrification procedures, have a normal medical, psychological and intellectual development according to children's age. The embryo and oocyte vitrification is a successful technique, and no negative effect had been found on assisted conception on developing human brain.