Neuromechanical modulation of transmembrane voltage in a model of a nerve.

Abstract

Despite substantial evidence that mechanical variables play a crucial role in transmembrane voltage regulation, most research efforts focus mostly on the nerve cell's biochemical or electrophysiological activities. We propose an electromechanical model of a nerve in order to advance our understanding of how mechanical forces and thermodynamics also regulate neural electrical activities. We explore the spatiotemporal dynamics of the transmembrane potential using the proposed nonlinear model with a sinusoid as the initial transmembrane potential and periodic boundary conditions. The localized wave from our numerical simulation and transmembrane potentials in nerves are solitary and show the three stages of action potential (depolarization, repolarization, and hyperpolarization), as well as threshold and saturation effects. We show that the mechanical properties of membranes affect the localization of the transmembrane potential. According to simulation data, mechanical pulses of sufficient magnitude can modulate a transmembrane voltage. The current model could be used to describe the dynamics of a transmembrane potential modulated by sound. Mechanical perturbations that modulate an electrical signal have a lot of clinical potential for treating pain and other neurological diseases.