Neuromagnetic Signatures of Abnormal Excitability of Motor Cortices in Adolescent Migraine

Abstract

Event Abstract Back to Event Neuromagnetic Signatures of Abnormal Excitability of Motor Cortices in Adolescent Migraine Xiaoshan Wang1*, Jing Xiang2, Yingying Wang2, Maria Pardos3, Lu Meng2, Scott W. Powers3, Marielle A. Kabbouche3 and Andrew D. Hershey3 1 Nanjing Brain Hospital, China 2 Cincinnati Children's Hospital Medical Center, United States 3 Cincinnati Children's Hospital Medical Center, Department of Neurology, United States Objective: The objective of the present study was to investigate the functional abnormalities of the motor cortices in adolescent migraine using magnetoencephalography (MEG) and a finger-tapping task. Background: Hyperexcitability of the primary somatosensory cortex has been reported in migraine using MEG. Many patients during a migraine also report difficulty with motor functioning. There is no report on motor-evoked magnetic activation in children with migraine with MEG and the latest signal processing methods. Methods: Ten children with migraine (all female, aged 13 to 17 years) and ten healthy children (all female, aged 12 to 17 years) were studied with a 275-channel MEG system. Each subject performed a brisk index finger tapping with either the right or the left index finger immediately after hearing a sound cue (500Hz, 30ms square tone); the stimuli consisted of 200 trials of square tone, 100 trials per ear, randomly distributed. The latency and amplitude of neuromagnetic responses were analyzed with averaged waveforms. Neuromagnetic sources were estimated using synthetic aperture magnetometry (SAM). SAM images were normalized for each participant for group comparison. Results: At least one neuromagnetic response was consistently identified in the MEG waveforms in the contralateral hemisphere to the unilateral finger tapping. In comparison to healthy children, children with migraine had prolonged latency of motor-evoked magnetic response in the right hemispheres during left finger movement (49.94±34.06 ms vs 21.21± 8.05 ms, p < 0.05). In addition, the SAM images indicated that children with migraine had stronger activation in the supplementary motor area during finger movement (8097.46±5168.99 vs 4697.54±3194.74, p < 0.05). Conclusion: The results suggest that there are measurable neuromagnetic abnormalities in children with migraine during finger tapping. The findings expand the ability to study the cerebral mechanisms of migraine and may facilitate the development of new therapeutic strategies in migraine treatment via alterations in cortical excitability with transcranial magnetic stimulation or other approaches. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: MEG: Clinical applications Citation: Wang X, Xiang J, Wang Y, Pardos M, Meng L, Powers SW, Kabbouche MA and Hershey AD (2010). Neuromagnetic Signatures of Abnormal Excitability of Motor Cortices in Adolescent Migraine. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00284 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Apr 2010; Published Online: 05 Apr 2010. * Correspondence: Xiaoshan Wang, Nanjing Brain Hospital, Nanjing, China, wangxiaoshan71@yahoo.com.cn Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Xiaoshan Wang Jing Xiang Yingying Wang Maria Pardos Lu Meng Scott W Powers Marielle A Kabbouche Andrew D Hershey Google Xiaoshan Wang Jing Xiang Yingying Wang Maria Pardos Lu Meng Scott W Powers Marielle A Kabbouche Andrew D Hershey Google Scholar Xiaoshan Wang Jing Xiang Yingying Wang Maria Pardos Lu Meng Scott W Powers Marielle A Kabbouche Andrew D Hershey PubMed Xiaoshan Wang Jing Xiang Yingying Wang Maria Pardos Lu Meng Scott W Powers Marielle A Kabbouche Andrew D Hershey Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.